发明名称 |
WATER SOLUBLE MULTI-BIOTIN-CONTAINING COMPOUNDS |
摘要 |
<p>Water soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water soluble biotin-containing compounds may additionally comprise one or more moieties that confer resistance to cleavage by biotinidase or that is cleavable <i>in vitro</i> or <i>in vivo</i>. The discrete multi-biotin-containing compounds may include a reactive moiety that provides a site for reaction with yet another moiety, such as a targeting, diagnostic or therapeutic functional moiety. Biotinylation reagents comprising water soluble linker moieties are also disclosed and may additionally comprise a biotinidase protective group. Methods for amplifying the number of sites for binding biotin-binding proteins at a selected target using multi-biotin compounds are also disclosed.</p> |
申请公布号 |
WO0072802(A8) |
申请公布日期 |
2001.04.19 |
申请号 |
WO2000US15081 |
申请日期 |
2000.06.01 |
申请人 |
UNIVERSITY OF WASHINGTON |
发明人 |
WILBUR, SCOTT, D.;PATHARE, PRADIP, M.;HAMLIN, DONALD, K.;WEERAWARNA, ANANDA, S. |
分类号 |
C07D495/04;C07D519/00;(IPC1-7):A61K/ |
主分类号 |
C07D495/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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