In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel

摘要

The invention relates to 5-substituted indolinones of general formula (I), where R<1> to R<5> and X are as defined in claim 1, the isomers and salts thereof, in particular, the physiologically acceptable salts, which exhibit valuable pharmacological properties. Said properties, in particular, include an inhibitory effect on various kinases and cyclin/CDK complexes, receptor thyrosine kinases and on the proliferation of tumour cells. The invention further relates to medicaments containing these compounds, use and methods for production thereof.