| 发明名称 |
HETEROCYCLIC SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD |
| 摘要 |
Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure (I) wherein n is 1 to 5; X is N or C-R<5> wherein R<5> is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl group, R<1>, R<2>, R<3> and R<4> are as defined herein, and where X is N, R<1> is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above heterocyclic derivatives.
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| 申请公布号 |
WO0127107(A2) |
申请公布日期 |
2001.04.19 |
| 申请号 |
WO2000US27461 |
申请日期 |
2000.10.02 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY;AHMAD, SALEEM;WU, SHUNG, C.;O'NEIL, STEVEN, V.;NGU, KHEHYONG;ATWAL, KARNAIL, S. |
发明人 |
AHMAD, SALEEM;WU, SHUNG, C.;O'NEIL, STEVEN, V.;NGU, KHEHYONG;ATWAL, KARNAIL, S. |
| 分类号 |
C07D233/64;A61K31/41;A61K31/415;A61K31/4164;A61K31/4168;A61K31/4172;A61K31/4178;A61K31/4196;A61K31/4245;A61K31/426;A61K31/427;A61K31/437;A61K31/4427;A61K31/4439;A61K31/454;A61K31/4545;A61K31/4745;A61K31/501;A61K31/505;A61K31/506;A61K31/513;A61K31/519;A61K31/5377;A61K45/00;A61P3/04;A61P3/06;A61P3/10;A61P7/02;A61P9/00;A61P9/04;A61P9/06;A61P9/10;A61P9/12;A61P13/12;A61P19/10;A61P25/28;A61P29/00;A61P43/00;C07D231/38;C07D233/54;C07D233/84;C07D233/88;C07D239/48;C07D277/20;C07D277/40;C07D401/04;C07D401/14;C07D403/04;C07D403/06;C07D403/08;C07D403/10;C07D405/08;C07D405/14;C07D409/04;C07D409/14;C07D413/08;C07D417/04;C07D417/08;C07D417/14;C07D471/02;C07D471/04;C07D487/04;C07D495/04;C07D513/04;(IPC1-7):C07D405/08 |
主分类号 |
C07D233/64 |
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