发明名称 |
Lentiviral vectors for the preparation of immunotherapeutical compositions |
摘要 |
<p>The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or sequence of interest) and regulatory signals of retrotranscription, expression and encapsidation of retroviral or retroviral-like origin, wherein the composition is capable of inducing or of stimulating a cell-mediated response for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response, against one or several epitopes encoded by the transgene sequence present in the vector.</p> |
申请公布号 |
EP1092779(A1) |
申请公布日期 |
2001.04.18 |
申请号 |
EP19990402492 |
申请日期 |
1999.10.11 |
申请人 |
INSTITUT PASTEUR;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
CHARNEAU, PIERRE;FIRAT, HUESEYIN;ZENNOU, VERONIQUE |
分类号 |
C12N15/09;A61K35/76;A61K39/00;A61K39/02;A61K39/04;A61K48/00;A61P31/00;A61P31/12;A61P35/00;C07K14/35;C12N5/10;C12N7/00;C12N7/01;C12N15/86;C12N15/867;(IPC1-7):C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|