Liposomal mixture of local anesthetics and manufacturing method thereof

摘要

An improved topical anesthetics cream consisting of mixture of local anesthetics such as lidocaine, tetracaine and cocaine and lipids including phosphotidylcholine, phosphatidyldioleoyl and cholesterol which provide faster effectiveness and long lasting anesthesia, and convenient administration and a method for the manufacture thereof, are disclosed. The lipids and the method of manufacture used to form the effective topical anesthesia are selected on the basis of their skin penetration and effect duration characters. The topical anesthetic effects of the liposomal mixture of local anesthetics and EMLA as a control was evaluated by pinprick test. Liposomal mixture of local anesthetics under no occlusion appeared to be improved formulation for topical anesthetics which lasted up to four hours after one hour application and exhibited fast onset time as approximately thirty minutes. EMLA was comparatively ineffective; it takes at least an hour to be effective and the duration lasted around two hours.