HYDROXYPROPYL CELLULOSE OF LOW DEGREE OF SUBSTITUTION

摘要

PURPOSE: Provided is hydroxypropyl cellulose of low degree of substitution, which has excellent particle characteristic and tablet property by setting the content of hydroxypropoxyl group and an apparent average degree of polymerization within specific ranges. CONSTITUTION: The hydroxypropyl cellulose contains 5.0-16.0wt% of hydroxypropoxyl group and has the apparent average degree of polymerization being 350-700, preferably 400-600. Further, the hydroxypropyl cellulose has a volume average particle size by a dry laser diffraction method of 10-100 micrometer and a bulk density (hardness) of 0.4-0.8g/ml. And the content of the hydroxypropyl cellulose in a tablet is preferably 5-50wt.%.