| 摘要 |
PURPOSE: Provided is a pharmaceutical composition for the treatment of migraine by incorporating a 5HT1 receptor agonist, a specific compound and a carrier. CONSTITUTION: The pharmaceutical composition contains: (a) a 5HT1 receptor agonist (for example, eletriptan, rizatriptan, zolmitriptan, sumatriptan, naratriptan); (b) a compound of formula(I), wherein R1 is sulfamyl; R2 is a haloalkyl; R3 is hydride, an alkyl; and R4 is a (substituted) aryl, a cycloalkyl or the like or formula(II), wherein R1 is a (carboxyl)alkyl, an alkoxycarbonyl or the like; R3 is a (substituted) cycloalkyl, a cycloalkenyl or the like and R4 is a lower alkyl, hydroxyl or amino, (preferably celecoxib or valdecoxib); and (c) a carrier.
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