| 摘要 |
Methods of inducing functional tolerance for the expression products of transgenes in somatic cells are disclosed, which methods comprise the introduction into the recipient of stem cells, such as hematopoietic stem cells, transgenically modified so as to express one or more neoantigens, such procedure optionally preceded by a myeloreductive procedure. The purpose of the disclosed methods is to induce tolerance to these same antigens when later expressed by cells or vectors to be introduced as part of a gene therapy treatment.
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