NOVEL ZINC FINGER PROTEIN

摘要

The invention relates to a nucleotide sequence encoding a novel zinc finger protein, and fragments and derivatives thereof, wherein the nucleotide sequence is upregulated in gene expression in senescent and quiescent cells. The invention also relates to an amino acid sequence of a novel zinc finger protein, and fragments and derivatives thereof wherein said sequence is characterized by eight tandemly repeated zinc fingers and the presence of a complete KRAB box which is necessary for transcriptional repression and localization of the protein to the nuclear matrix. The invention also relates to the novel zinc finger protein being a transcriptional activator, particularly in the presence of a coactivator.