METHOD FOR IMPROVING THE SOLUBILITY OF TRICYCLIC AMINO ALCOHOL DERIVATIVES

摘要

Compounds useful in the treatment and prevention of diabetes, obesity, hyperlipidemia and so on are provided in the form of oral preparations exhibiting good absorbability in the digestive tract. A method for improving the solubility of tricyclic amino alcohol derivatives of general formula (1) or salts thereof, characterized by using these derivatives or salts in the form of noncrystalline substance, wherein R1 is lower alkyl or benzyl; * represents an asymmetric carbon atom; R2 is hydrogen, halogeno, or hydroxyl; and A is a substituent represented by general formula (2) or (3), (wherein X is NH, O or S).