发明名称 |
NOVEL NICOTINONITRILE COMPOUNDS |
摘要 |
The present invention relates to a selective inhibitor of mammalian osteoclast cell activity, processes for its preparation and pharmaceutical compositions comprising the same as well as methods of treatment, where said selective inhibitor is administered to a human or animal patient. Said selective inhibitor has been found to inhibit vacuolar H<+>-ATPase, such as vacuolar H<->ATPase in osteoclast cells, whereby it is therapeutically efficient against physiological disorders involving bone resorption. In an embodiment of the present invention, said selective inhibitor comprises a nicotinonitrile compound with general formula (I). |
申请公布号 |
WO0125207(A1) |
申请公布日期 |
2001.04.12 |
申请号 |
WO2000SE01857 |
申请日期 |
2000.09.26 |
申请人 |
ASTRAZENECA AB;HERSLOEF, MARGARETA;SOERENSEN, HENRIK |
发明人 |
HERSLOEF, MARGARETA;SOERENSEN, HENRIK |
分类号 |
A61K31/4409;A61K31/443;A61K31/4439;A61K31/455;A61P1/02;A61P3/10;A61P5/48;A61P9/10;A61P17/06;A61P19/08;A61P19/10;A61P25/28;A61P27/02;A61P29/00;A61P31/18;A61P35/00;A61P43/00;C07D213/85;C07D401/04;C07D405/04;C07D405/10 |
主分类号 |
A61K31/4409 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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