UREA COMPOUNDS, THEIR PRODUCTION AND USE

摘要

Compounds represented by general formula (I) or salts thereof which exhibit an excellent CCR5 antagonism and are useful as preventives and remedies for HIV infection of human peripheral blood mononuclear cells, in particular, AIDS, wherein R1 represents optionally substituted hydrocarbyl; R2 represents optionally substituted cyclic hydrocarbyl or an optionally substituted heterocycle; R3 represents halogeno, optionally substituted carbamoyl, optionally substituted sulfamoyl, sulfonate-origin acyl, optionally substituted C1-4 alkyl, optionally substituted C1-4 alkoxy, optionally substituted amino, nitro or cyano; R4 represents hydrogen or hydroxy; n is 0 or 1; and p is 0 or an integer of from 1 to 4.