USE OF SOLUBLE COSTIMULATORY FACTOR FOR TUMOR IMMUNO-GENE THERAPY

摘要

A new gene therapy entails tumor treatment by introducing an expressible nucleotide sequence for a soluble costimulatory factor, thereby enhancing th e response of T-cells to a tumor. In vivo expression of the soluble factor overcomes anergy or tolerance to tumor cells and activates T-cells that are infiltrating or surrounding the tumor. A pharmaceutical composition containi ng such a gene is effective in tumor suppression.