Nucleic acids encoding a functional human purinoreceptor P2X3 and P2X6, and methods of production and use thereof

摘要

Human P2X3 and P2X6 purinergic receptor polypeptides are provided. Nucleic acid molecules encoding the aforementioned human P2X receptor polypeptide, and vectors and host cells containing such nucleic acid molecules, are also provided. In addition, methods are provided for producing these P2X receptor polypeptide, as are methods of using such polypeptides and host cells that express the same to screen for compounds having activity on P2X3 and P2X6 receptors. Further, therapeutic uses involving aspects of these receptors are contemplated.