发明名称 Macrocyclic analogs and methods of their use and preparation
摘要 The invention provides halichondrin analogs having pharmaceutical activity, such as anticancer or antimitotic (mitosis-blocking) activity, and methods of identifying agents that induce a sustained mitotic block in a cell after transient exposure of the cell to the agents.
申请公布号 US6214865(B1) 申请公布日期 2001.04.10
申请号 US19990334488 申请日期 1999.06.16
申请人 EISAI CO., LTD. 发明人 LITTLEFIELD BRUCE A.;PALME MONICA H.;SELETSKY BORIS M.;TOWLE MURRAY J.;YU MELVIN J.;ZHENG WANJUN
分类号 C07D491/22;A61K31/55;A61P35/00;C07D493/22;C12Q1/00;(IPC1-7):A61K31/335;C07D321/02 主分类号 C07D491/22
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