发明名称 |
Macrocyclic analogs and methods of their use and preparation |
摘要 |
The invention provides halichondrin analogs having pharmaceutical activity, such as anticancer or antimitotic (mitosis-blocking) activity, and methods of identifying agents that induce a sustained mitotic block in a cell after transient exposure of the cell to the agents.
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申请公布号 |
US6214865(B1) |
申请公布日期 |
2001.04.10 |
申请号 |
US19990334488 |
申请日期 |
1999.06.16 |
申请人 |
EISAI CO., LTD. |
发明人 |
LITTLEFIELD BRUCE A.;PALME MONICA H.;SELETSKY BORIS M.;TOWLE MURRAY J.;YU MELVIN J.;ZHENG WANJUN |
分类号 |
C07D491/22;A61K31/55;A61P35/00;C07D493/22;C12Q1/00;(IPC1-7):A61K31/335;C07D321/02 |
主分类号 |
C07D491/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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