发明名称 |
Hepatitis E virus antigens and uses therefor |
摘要 |
Antigens are provided which are derived from the enterically transmitted non-A/non-B viral hepatitis agent, known as hepatitis E virus (HEV). The HEV antigens and in particular, soluble species of the capsid protein encoded by the carboxy terminal region of HEV ORF2, are immunoreactive with sera from individuals infected with HEV. In one embodiment, these antigens may be produced by a baculovirus expression vector and form virus-like particles (VLPs). The antigens are useful as diagnostic reagents in diagnostic methods and kits for determining infection of an individual with HEV. The antigens are also useful in vaccine compositions effective in methods for preventing HEV infection.
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申请公布号 |
US6214970(B1) |
申请公布日期 |
2001.04.10 |
申请号 |
US19950542634 |
申请日期 |
1995.10.13 |
申请人 |
GENELABS TECHNOLOGIES, INC. |
发明人 |
FUERST THOMAS R.;MCATEE C. PATRICK;YARBOUGH PATRICE O.;ZHANG YI-FAN |
分类号 |
G01N33/576;A61K38/00;A61K39/00;A61K39/29;A61K48/00;A61P31/12;C07K14/08;C07K16/10;C12N15/00;C12N15/09;C12N15/40;C12P21/02;C12Q1/70;C12R1/91;C12R1/92;(IPC1-7):C07K14/08 |
主分类号 |
G01N33/576 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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