| 发明名称 |
Multideterminant peptides that elicit helper T-lymphocyte, cytotoxic T lymphocyte and neutralizing antibody responses against HIV-1 |
| 摘要 |
The invention is directed to peptides of the HIV-1 envelope protein presenting multiple immune determinants. The peptide elicits both humoral and cell-mediated immune responses in mice having a variety of MHC types. In other embodiments, the invention is directed to immunogens composed of the peptides and methods for immunization employing them.
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| 申请公布号 |
US6214347(B1) |
申请公布日期 |
2001.04.10 |
| 申请号 |
US19950455685 |
申请日期 |
1995.05.31 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
BERZOFSKY JAY A.;AHLERS JEFFREY D.;PENDLETON C. DAVID;NARA PETER;SHIRAI MUTSUNORI |
| 分类号 |
A61K39/00;A61K38/00;A61K38/03;A61K38/55;A61P31/12;A61P31/18;A61P37/02;C07K14/155;C07K14/16;C07K19/00;(IPC1-7):A61K39/21 |
主分类号 |
A61K39/00 |
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