Food grade saponins as oral adjuvants

摘要

There is a need for effective oral vaccine adjuvants. Saponin extracts are effective adjuvants but are toxic, so purified saponins have previously been suggested. The invention provides food grade saponins for use as oral adjuvants. This avoids the toxicity problems of the crude extracts and the expense problems of the purified saponin extracts and fractions, whilst simultaneously utilising substances which already have approval for human ingestion.