IMMUNOCONJUGATE, METHOD OF POLYNUCLEOTIDE DELIVERY INTO SPECIFIC CELLS TYPE, METHOD OF DELIVERY OF CYTOTOXIC GELONINE INTO CELL

摘要

medicine, genetic therapy, molecular biology. SUBSTANCE: invention proposes immunoconjugate containing biotin-binding element that is conjugated with biotinylated fragment. Also, invention proposes method of delivery of genetic material into the specific cell involving administration of immuniconjugate in humans. Indicated nonviral vector contains component binding with cell containing biotin-binding element that is conjugated with biotinylated fragment. Also, invention proposes method of transfer of cytotoxic gelonine to the cell involving administration of immunoconjugate in humans. New system of delivery of genetic material provides to modify harmful or nondesirable phenotypic traits. EFFECT: improved properties. 11 cl, 11 dwg, 15 ex