发明名称 |
DNA SEQUENCE, A POLYPEPTIDE HAVING HEMATOPOIETIC BIOLOGICAL PROPERTY, THE USE THEREOF, A PHARMACEUTICAL COMPOSITION, METHOD OF TRANSFECTION AND CELLS CULTIVATION, A KIT AND AN ANTIBODY |
摘要 |
DNA sequence useful for the expression of a polypeptide product exhibiting a hematopoietic biological activity of naturally occurring stem cell factor in procaryotic or eukaryotic host cell. Use of the polypeptide for the production of a drug useful in the hematopoietic therapy of a mammal. Pharmaceutical composition containing an effective amount of said polypeptide and a pharmaceutically acceptable solvent, additive or carrier. A method of transfecting hematopoietic cells with an exogenous DNA during which said hematopoietic cells are cultivated by said polypeptide and the cultivated cells are transfected with exogenous DNA sequence. A method of hematopoietic cells cultivation in vitro in a cultivation medium which contains said polypeptide. An assay containing components for the cultivation of bone marrow cells or peripheral blood progenitors containing i) said polypeptide, optionally on a pharmaceutically acceptable carrier, ii) components useful in preparing medium for the cultivation of bone marrow cells or peripheral blood progenitors. An antibody selectively binding for said polypeptide.
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申请公布号 |
SK500890(A3) |
申请公布日期 |
2001.04.09 |
申请号 |
SK19900005008 |
申请日期 |
1990.10.15 |
申请人 |
AMGEN INC. |
发明人 |
ZSEBO KRISZTINA M.;SUGGS SIDNEY VAUGHN;BOSSELMAN ROBERT A.;MARTIN FRANCIS HALL |
分类号 |
C12N15/12;A61K38/00;A61K38/18;A61K38/19;A61K47/48;A61K48/00;A61P7/00;A61P7/04;A61P7/06;A61P35/00;A61P37/02;C07K;C07K1/36;C07K14/00;C07K14/475;C07K14/535;C07K16/22;C12N;C12N1/21;C12N5/10;C12N15/19;C12N15/64;C12N15/70;C12N15/79;C12P;C12P21/02;C12P21/08;C12R1/19;(IPC1-7):C12N15/12 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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