| 摘要 |
PURPOSE: A method for producing 1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid having an optical activity is provided, thereby the compound can be produced in a high yield with low cost. CONSTITUTION: The method for producing 1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid having an optical activity comprises the steps of: reacting phenylalanine or its derivatives with formaldehyde or paraformaldehyde in hydrochloric acid containing sulfuric acid and sodium chloride to produce 1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid hydrochloride; dissolving the hydrochloride into water and adding base to produce 1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid, in which the phenylalanine or its derivatives are represented by formula (1), wherein R1, R2, and R3 are individually hydrogen, hydroxy, lower alkyl, aryl, C1 to C7 alkoxy or halogen; R1 and R2 together or R2 and R3 together may form -OCH2O- ring.
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