| 摘要 |
PURPOSE: A process for preparing the title compounds by reaction of 2-halogen aniline with a halogen molecular in the presence of a phase transition catalyst and an organic solvent and then the obtained half product with benzene and sodium nitrite or isoamyl nitrite is provided which can mass-produce biphenyl derivatives substituted with halogen at the 2, 4-position at low cost. CONSTITUTION: The subject biphenyl derivatives of formula 1 substituted halogen at the 2, 4-position are prepared by a process consisting of: preparing aniline acid salt derivatives substituted with halogen at the 2, 4-position of formula 3 by reaction of 2-halogen aniline of formula 2 with halogen in the presence of a phase transition catalyst and an organic solvent; and reacting the obtained aniline acid salt derivatives substituted with halogen at the 2, 4-position with sodium nitrite or isoamyl nitrite and benzene in the presence of an acid aqueous solution. In formula, X1, X2, X are each independently halogen.
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