发明名称 METHOD FOR MANUFACTURING ISO-OXAZOLE PIPERAZIN COMPOUND AND LIBRARY MANUFACTURED THEREBY
摘要 PURPOSE: Provided is a method for manufacturing an iso-oxazole piperazin compound and its salts which can end up developing a lead compound for new drugs. CONSTITUTION: An isooxazol compound is manufactured by the next step: reacting the compound of the formula (2) with the compound of the formula (3) at room temperature, at 0-7 deg.C, in the presence of organic solvent, 0.1-2 equivalent, preferably 1 equivalent of base, and chlorinating agent for 30 minutes-4 hours, preferably 2 hours. Wherein, organic solvent is selected from benzene, methylene chloride, and tetrahydrofuran; a base is selected from methyl amine, ethyl amine, diethyl amine, dimethyl amine, trimethyl amine, cyclohexylamine, diethylisopropylamine, pyridine, or preferably triethylamine; And chlorinating agent is one of chlorine, N-chlorosuccinimide, and sodium hypochlorite. In the formula (1), (2), and (3), R1 and R6 are a phenyl group, benzyl group, halide phenyl group, phenyl group having substituted C1-C6 alkyl group, phenyl group having substituted C1-C6 alkoxy group, methyl phenyl group, or pyridyl group. R2-R5 is hydrogen, and X is nitrogen.
申请公布号 KR20010029025(A) 申请公布日期 2001.04.06
申请号 KR19990041613 申请日期 1999.09.28
申请人 KOREA INSTITUTE OF CONSTRUCTION TECHNOLOGY 发明人 BAE, AE NIM;CHO, YONG SEO;CHOI, GYEONG IL;JUNG, DAE YEONG;JUNG, SEON HO;KANG, GYEONG HO;KO, HUN YEONG;KONG, JAE YANG;LEE, HUI YUN;LEE, JI EUN
分类号 C07D413/06;(IPC1-7):C07D413/06 主分类号 C07D413/06
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