ANTI-HYPERCHOLESTEROLEMIC DRUG COMBINATION

摘要

This invention provides a drug combination comprised of an HMG-CoA reductase inhibitor with an ACAT inhibitor in synergistic therapeutically effective amounts, which is useful for reducing cholesterol synthesis, lowering plasma LDL cholesterol levels and lowering plasma triglyceride levels. Profound synergy can be achieved only when the ACAT inhibitor is administered in low dosage amounts, above which the beneficial synergistic effects diminish and disappear.