QUINUCLIDINE COMPOUNDS AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

摘要

Compounds represented by general formula (I), salts thereof, or hydrates of both, useful as excellent squalene synthase inhibitors wherein R<1> is hydrogen or hydroxyl; HAr is an optionally substituted aromatic heterocycle; Ar is an optionally substituted aromatic ring; W is (1) a -CH2-CH2- group which may be substituted, (2) a -CH=CH- group which may be substituted, (3) -CC-, (4) -NH-CO-, or the like; and X is a single bond, optionally substituted C1-6 alkylene, (5) -Q- [wherein Q is oxygen, sulfur, CO, or N(R<2>) (wherein R<2> is C1-6 alkyl or C1-6 alkoxy)], (6) -NH-CO-, or the like.