PYRIMIDINE DERIVATIVES, PROCESS FOR PREPARING THE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

摘要

Pyrimidine derivatives of general formula (I) or nontoxic salts thereof, useful as intermediates for the synthesis of drugs and/or as drugs, particularly elastase inhibitors. In formulas (I) and (II) R1 is H or F; R2 is -CH(OR3)2, CHO, COOH, alkoxycarbonyl, furan-2-yl, a group of general formula (II), or the like; R3 is Me or Et; and R4 is alkyl, phenyl, (substituted) benzyl, or the like.