| 摘要 |
The polynucleotide and polypeptide sequences of two novel hypoxia-inducible human genes, <i>HIG1</i> and <i>HIG2</i>, are described. In addition, a number of known genes and ESTs have now been established as being hypoxia-inducible and hypoxia-repressible. Polynucleotide and polypeptide arrays comprising the hypoxia-inducible and hypoxia-repressible gene sequences, proteins, or antibodies which specifically bind the proteins are disclosed. Methods for using the hypoxia-inducible and hypoxia-repressible gene sequences and proteins, and arrays thereof, to diagnose and treat hypoxia-related conditions such as cancer and ischemia are also provided.
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| 申请人 |
VARIAN ASSOCIATES, INC.;DENKO, NICHOLAS, C.;GIACCIA, AMATO, J.;GREEN, CHRISTOPHER, J.;LADEROUTE, KEITH, R.;SCHINDLER, CORNELIA;KOONG, ALBERT, CHING-WEI |
发明人 |
DENKO, NICHOLAS, C.;GIACCIA, AMATO, J.;GREEN, CHRISTOPHER, J.;LADEROUTE, KEITH, R.;SCHINDLER, CORNELIA;KOONG, ALBERT, CHING-WEI |
