New peptaibol peptides produced by Sepedonium fungus, useful as antibacterial, antifungal, neuroleptic and anxiolytic agents

摘要

Peptaibols (I), i.e. peptides rich in alpha -aminoisobutyric acid (Aib) residues, produced by the fungus of the Sepedonium species (DSM 10602), are new. Peptaibols (I) of formula (Ia) and (Ib) are new: N-acetyl-L-Trp-L-Ala-Aib-Aib-L-Leu-Aib-L-Gln-X-L-Gln-L-Leu-Aib-L-Gln-L -leucinol (Ia) N-acetyl-L-Trp-L-Ala-Aib-Aib-L-Leu-Aib-L-Gln-L-Ala-Aib-Aib-L-Gln-L-Leu -L-Ala-L-Gln-L-leucinol (Ib) X = L-Ala-Aib-Aib, Aib-L-Ala-Aib or Aib-Aib-L-Ala. An Independent claim is also included for a process for producing (I).