| 摘要 |
Novel fused imidazole compounds of general formula (I), pharmacologically acceptable salts thereof, or hydrates of both, exhibiting adenosine A2 receptor antagonism and being effective in the prevention and treatment of diabetes mellitus and complications of diabetes; wherein R<1> is optionally alkylated amino or the like; R<2> is hydrogen, alkyl, or the like; R<3> is optionally substituted aryl, a pyridinone group, a pyrimidinone group, or the like; Ar is an optionally sybstituted aryl or heteroaryl group, or the like; and Q and W are each independently N or CH.
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| 申请人 |
EISAI CO., LTD.;ASANO, OSAMU;HARADA, HITOSHI;YOSHIKAWA, SEIJI;WATANABE, NOBUHISA;INOUE, TAKASHI;HORIZOE, TATSUO;YASUDA, NOBUYUKI;OOHASHI, KAYA;MINAMI, HIROE;NAGAOKA, JUNSAKU;MURAKAMI, MANABU;KOBAYASHI, SEIICHI;TANAKA, ISAO;KAWATA, TSUTOMU;SHIMOMURA, NAOYUKI;AKAMATSU, HIROFUMI;OZEKI, NAOKI;SHIMIZU, TOSHIKAZU;HAYASHI, KENJI;HAGA, TOYOKAZU;NEGI, SHIGETO;NAITO, TOSHIHIKO |
发明人 |
ASANO, OSAMU;HARADA, HITOSHI;YOSHIKAWA, SEIJI;WATANABE, NOBUHISA;INOUE, TAKASHI;HORIZOE, TATSUO;YASUDA, NOBUYUKI;OOHASHI, KAYA;MINAMI, HIROE;NAGAOKA, JUNSAKU;MURAKAMI, MANABU;KOBAYASHI, SEIICHI;TANAKA, ISAO;KAWATA, TSUTOMU;SHIMOMURA, NAOYUKI;AKAMATSU, HIROFUMI;OZEKI, NAOKI;SHIMIZU, TOSHIKAZU;HAYASHI, KENJI;HAGA, TOYOKAZU;NEGI, SHIGETO;NAITO, TOSHIHIKO |
