发明名称 |
PCA3 MESSENGER RNA SPECIES IN BENIGN AND MALIGNANT PROSTATE TISSUES |
摘要 |
This invention concerns the discovery of two distinct PCA3 mRNA sequences. O ne of these sequences corresponds to a short PCA3 mRNA molecule whereas the oth er PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer whereas the long RNA sequence is associated with a non-malignant state of the prostate. Based on the differential expression levels of these two PCA3 RNA sequences, protocols for the diagnosis of prostate disease are provided. The invention also relates to therapeutic approaches to prostate cancer. |
申请公布号 |
CA2385477(A1) |
申请公布日期 |
2001.04.05 |
申请号 |
CA20002385477 |
申请日期 |
2000.09.29 |
申请人 |
DIAGNOCURE INC. |
发明人 |
BUSSE, URSULA;CHYPRE, CAMILLE;FRADET, YVES |
分类号 |
A01K67/027;A61K31/7088;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P13/08;A61P35/00;A61P43/00;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/02;C12N15/09;C12N15/12;C12Q1/68;G01N33/53;G01N33/566;G01N33/574;G01N33/577 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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