Tocol-based compositions of charged amphiphilic and water soluble pharmaceutically active compounds or their charged precursors are prepared by forming a tocol-soluble ion pair with an oppositely charged ion-pair forming compound capable of forming a tocol-soluble ion-pair with the active compound. Also disclosed are novel compounds tocopherolsuccinate-aspartate and tocopherolsuccinate-glutamate, which are useful as ion-pair forming compounds.
申请公布号
WO0122937(A1)
申请公布日期
2001.04.05
申请号
WO2000US26467
申请日期
2000.09.27
申请人
SONUS PHARMACEUTICALS, INC.;CONSTANTINIDES, PANAYIOTIS;LAMBERT, KAREL;TUSTIAN, ALEXANDER;NIENSTEDT, ANDREW
发明人
CONSTANTINIDES, PANAYIOTIS;LAMBERT, KAREL;TUSTIAN, ALEXANDER;NIENSTEDT, ANDREW