<p>The present invention provides an assay for determining the biochemical fitness of a biochemical species in a mutant replicating biological entity relative to its predecessor. The present invention further provides a continuous fluorogenic assay for measuring the anti-HIV protease activity of protease inhibitor. The present invention also provides a method of administering a therapeutic compound that reduces the chances of the emergence of drug resistance in therapy.</p>
申请公布号
EP1088098(A2)
申请公布日期
2001.04.04
申请号
EP19990931861
申请日期
1999.06.23
申请人
UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND SOCIAL SERVICES
发明人
ERICKSON, JOHN, W.;GULNIK, SERGEI, V.;MITSUYA, HIROAKI;GOSH, ARUN K.
