A METHOD OF INDUCING AN IMMUNE RESPONSE USING VACCINIA VIRUS RECOMBINANTS
摘要
A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
申请公布号
EP0759695(A4)
申请公布日期
2001.04.04
申请号
EP19950919799
申请日期
1995.05.11
申请人
THOMAS JEFFERSON UNIVERSITY
发明人
MASTRANGELO, MICHAEL, J.;LATTIME, EDMUND, C.;BERD, DAVID;EISENLOHR, LAURENCE, C.