WATER-SOLUBLE PRESSURE-SENSITIVE MUCOADHESIVE

摘要

Water-soluble pressure-sensitive adhesives include a water-soluble polymer t hat is made tacky at room temperature by addition of a water-soluble plasticizer that is miscible with the polymer. Suitable poly mers are solid at room temperature; and have a hydrophil icity as measured by water uptake greater than about 25 %; they are liquid at room temperature and have a boiling point higher than about 80 .degree.C. The adhesives according to the invention may conveniently be prov ided in dry film form. Preferred water-soluble pressure- sensitive adhesives of the invention adhere both to mucosal surfaces and to a variety of materials that may constitute a part of a device or p rosthesis to be held in a body cavity that has a mucosal lining. Also, a laminated device for the controlled release of a substance within a muco sa-lined body cavity includes the substance dissolved or dispersed in either or both of a water-soluble pressure-sensitive adhesive layer and optionally one or more water-soluble polymer layers. Also, devices for administering a substance over an extended time for relief of sore throa t or cough, or for administering a breath freshening agent, particularly a mint o dorant, include a water soluble polymer film layer conta ining the active ingredient, and a water soluble pressure sensitive mucoadhesive l ayer.