NEW BICYCLONUCLEOSIDE ANALOG

摘要

PROBLEM TO BE SOLVED: To provide a new bicyclonucleoside analog having anti-AIDS activity and provide an intermediate for the production of an oligonucleotide analog having excellent antisense or antigene activity and stable in living body. SOLUTION: The objective compound is expressed by structural formula (1) [R1 groups are each same or different H or hydroxyl-protecting group; R2 is azide group, a (protected)amino or the like; B is purin-9-yl or 2-oxo-1,2- dihydropyrimidin-1-yl which may have substituent selected from halogen atom, 1-6C alkyl, hydroxyl, mercapto, amino or the like] or its pharmacologically permissible salt.