Jak kinases and regulation of cytokine signal transduction

摘要

Provided are methods for regulating the cellular response to cytokines by inhibiting or enhancing of at least one Jak kinase activity which mediates the response; assays for identifying inhibitors of Jak kinase activity or cytokine-induced Jak kinase activation useful in the methods of the invention are also provided; antibodies raised against peptide fragments of at least one epitope specific for a Jak kinase without interfering with kinase activity; polypeptides for Jak kinases; and nucleic acid encoding therefor.