| 摘要 |
PROBLEM TO BE SOLVED: To obtain a compound having CD40 function-inhibiting action. SOLUTION: This pyrimidine derivative is a compound having the general formula (I) R1, R3 and R4 are each H, OH, a halogen, an alkyl, an alkoxy, an alkylthio, a halogenated alkyl, an aryl which may be substituted, an heteroaryl which may be substituted, an aralkyl which may be substituted or N(Ra)Rb [Ra and Rb are each H, OH, an alkyl, a cycloalkyl, an aryl which may be substituted, a heteroaryl which may be substituted, an aralkyl which may be substituted or the like]; R2 is NO2, CN, COOH or an alkoxycarbonyl (R1 and R2 together may form a cyclic group); X and Y are each N or CH) or its pharmacologically permissible salt.
|
