Cycloalkyl, lactam, lactone and analogs, and pharmaceutical compositions

摘要

Provided are compounds of the formula depicted, wherein: R1 is selected from optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl, and aryl, heteroaryl and heterocyclic; W, together with the rest of the ring structure forms an optionally substituted, optionally further ring fused cycloalkyl, cycloalkenyl or heterocyclic ring; X is O, S, hydroxy (H, OH), mercapto (H, SH) and dihydro (H, H); Y is -NH-CO-CHR2- and R2 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heteroaryl; Z is -TCX'X"C(O)- and T is a covalent bond, O, S, or NR5; X' is H, OH or F; X" is H, OH or F, or X' and X" together form an oxo group; m is 0 or 1; n is 0, 1, or 2; p is 0 or 1 such that when p is 0, the ring group is unsaturated at the carbon atom of the ring attachment to Y and when p is 1, the ring group is saturated at the carbon atom of the ring attachment to Y. Such compounds are report to have application for inhibiting b-amyloid peptide release and/or its synthesis in a cell.