Diagnosis of susceptibility to cancer using nucleic acid probes

摘要

The susceptibility of a patient to cancer may be determined by contacting a sample of nucleic acid, with a nucleic acid which selectively hybridises to human-derived DNA of the YAC 821-D-2, which is part of the CEPH mega-YAC library, Human Genome Mapping Project Resource Centre, or which selectively binds to the region of human chromosome 10 which region is bounded by DNA defined by the markers D10S541 and D10S215. The sample of nucleic acid is taken from blood, urine, semen or prostate tissue. The sequence of a nucleic acid capable of selectively hybridising to the region of human chromosome 10 bounded by DNA defined by the markers D10S541 and D10S215 is defined in the specification. The nucleic acids described above may be used in a medicament for the treatment of cancer.