REGULATION OF THE STABILITY OF RECOMBINANT PROTEINS AND ANTIBOODIES

摘要

An antibody to a drug of interest is caused to be expressed in a target cell of interest by genetic therapy. This antibody is expressed along with a promoter and modulator for the antibody. The drug is administered to the patient, where it binds to the antibody for the drug until a critical concentration of drug is reached at the target site. Once this critical concentration of drug is achieved, the antibody is released from the drug/antibody conjugate, and the drug is available at the target site in concentrations sufficient to treat the condition for which the drug is administered. In order to ensure that the antibodies are degraded at the proper time, the antibodies are designed to have built-in signals for degradation.