| 摘要 |
<p>An approach to establishing the clinical utility of a molecular target entails bringing a large quantity of different tissue samples into contact, in a high-throughput manner, with a stain that specifically binds a target molecule in situ, and then determining the extend to which the stain has bound the target molecule in the tissue samples. To this end, apparatus can be employed that comprises (i) a tissue microarray, having hundreds of small tissue samples upon which reagents may be applied; (ii) an automated staining instrument for applying reagents to the tissue samples and then carrying out most of the steps required for in situ hybridization and immunohistochemistry, and (iii) an imaging instrument to allow a user readily to ascertain the presence and/or the quantity of target in each of the samples.</p> |
