| 摘要 |
Peptides (I) with an amino acid sequence corresponding a beta 1-adrenergic receptor group recognized by autoantibodies associated with dilatative cardiomyopathy (DCM) are new. Peptides (I) having an amino acid sequence of formula (Ia) or (Ib) are new: Ia = X1-X2-X3-G-X4-X5-X6-X7-X8-X9-X10-X11-X12 Ib = Y1-Y2-Y3-R-Y4-Y5-Y6-Y7-Y8-E-A-R-Y9-Y10-Y11-Y12-Y13-Y14-Y15-Y16-Y17 X1 = an amino group, acetyl group, biotin group, fluorescence marker, spacer, linker or deletion; X2 = D, G, E, T, S or a deletion; X3 = W, Y, F, G or T; X4 = T, S, A or G; X5 = V, I, W, F or Y; X6 = L, F, Y or W; X7 = S, A or C; X8 = G, D, E, N or Q; X9 = F, L, I or Y; X10 = E, Q, T, S or L; X11 = Y, F, T, S or W; X12 = amide, GKK or a spacer; Y1 = an amino group, amino acid, peptide, acetyl group, biotin group, fluorescence marker, spacer, linker or deletion; Y2 = H, E or Q; Y3 = H, F, Y or W; Y4 = A or V; Y5 = G, T, E, S, D or N; Y6 = S, H or A; Y7 = D, N, Q or E; Y8 = G, A or a deletion; Y9 = D, N or R; Y10 = S, T, C or M; Y11 = H, F, W or Y; Y12 = A, D, N or S; Y13 = D or N; Y14 = E or P; Y15 = R, K or T; Y16 = S, T, C, M or a deletion; Y17 = amide, GKK, SGKK or a spacer. An Independent claim is also included for a chromatographic device comprising (I) bound to a solid phase.
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