QUINAZOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The use of a compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, NH or NR<8> where R<8> is hydrogen or C1-6alkyl; R is a 3-quinoline group or a group of sub-formula (i) where R<5>, R<6> and R<7> are various specific organic groups, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Novel compounds of formula (I) and pharmaceutical compositions useful in the treatment of cancer are also described and claimed.