摘要 |
The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site. |
申请人 |
THE GOVERNMENT OF THE UNITED STATE OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;LEPPLA, STEPHEN, H.;LIU, SHI-HUI;NETZEL-ARNETT, SARAH;HANSEN-BIRKEDAL, HENNING;BUGGE, THOMAS |
发明人 |
LEPPLA, STEPHEN, H.;LIU, SHI-HUI;NETZEL-ARNETT, SARAH;HANSEN-BIRKEDAL, HENNING;BUGGE, THOMAS |