| 摘要 |
<p>The present invention relates to a method of identifying an agent that corrects a defective three dimensional conformation of a polypeptide, by contacting in a cell-free system a peptide portion of the polypeptide with a test agent, wherein the peptide is representative of a region of the polypeptide containing the defective conformation; and determining that the test agent decreases the defective conformation of the peptide. The present invention also relates to a virtual representation of a peptide portion of a polypeptide, wherein the peptide is representative of a region of a polypeptide having a defective three dimensional conformation.</p> |
