发明名称 |
Prion protein modulator factor (PPMF) and prion resistant animals |
摘要 |
<p>Molecules are disclosed that interact with the cellular components involved in conversion of PrPC to PrPSc. The molecules disclosed can be small molecules, peptides or protein analogs, e.g. analogs of PrPC. In one embodiment, these molecules interfere with prion formation and/or replication, e.g. by preventing interactions of proteins involved in a prion complex or by interfering with beta-sheet formation. In another embodiment, the molecules of the invention promote PrPC conversion to PrPSc, e.g. by binding to PrPC and facilitating a conformational change from PrPC to PrPSc.</p> |
申请公布号 |
AU731291(B2) |
申请公布日期 |
2001.03.29 |
申请号 |
AU19980077967 |
申请日期 |
1998.05.18 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
STANLEY B PRUSINER;FRED E. COHEN;THOMAS L. JAMES;KIYOTOSHI KANEKO |
分类号 |
A01K67/027;A61K31/4164;A61K31/417;A61K31/4172;A61K31/4178;A61K31/662;A61K31/7064;A61K31/7076;A61K31/7084;A61K38/00;A61K45/00;A61P25/00;A61P43/00;C07H21/00;C07K1/04;C07K14/47;C07K16/18;C12N5/10;C12N15/09;C12Q1/02;G01N33/53;(IPC1-7):A61K38/00;C07H21/04;C07H21/02;C07K1/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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