| 摘要 |
<p>Amide derivatives of 1,4 di-substituted piperidine compounds of formula (I) or a pharmaceutically acceptable salt, ester or solvate thereof, wherein Q and Q1 are each -CH=, or one of Q and Q1 is -CH= and the other is -N=; X is -CH¿2?- or (a); Y and Z are -C(R?5¿)=, or one of Y and Z is -C(R5)= and the other is -N=; R1 is 1 to 3 substituents selected from H, halogen and alkoxy; R?2 and R5¿ are 1 to 3 substituents selected from H, halogen, alkyl and alkoxy; and R?3 and R4¿ are H or (C¿1?-C6) alkyl are muscarinic antagonists usuful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed.</p> |
