Verfahren zum Nachweis von oxidierten Formen der löslichen Guanylatzyklase und Verfahren zum Screening nach Aktivatoren der löslichen Guanylatzyklase mit oxidiertem Hämeisen

摘要

The invention relates to a method for the detection of a soluble guanylate cyclase, whose haem iron is present in a trivalent oxidation state and a method for detecting chemical substances which stimulate the activity of soluble guanylate cyclase when said haem iron present in soluble guanylate cyclase is at least in part trivalently oxidized. Said invention also relates to a diagnostic agent for detecting a soluble guanylate cyclase containing trivalent haem iron.