MUSCARINIC ANTAGONISTS

摘要

Amide derivatives of 1,4 di-substituted piperidine compounds of formula (I) or a pharmaceutically acceptable salt, ester or solvate thereof, wherein Q and Q<1> are each -CH=, or one of Q and Q<1> is -CH= and the other is -N=; X is -CH2- or (a); Y and Z are -C(R<5>)=, or one of Y and Z is -C(R<5>)= and the other is -N=; R<1> is 1 to 3 substituents selected from H, halogen and alkoxy; R<2> and R<5> are 1 to 3 substituents selected from H, halogen, alkyl and alkoxy; and R<3> and R<4> are H or (C1-C6) alkyl are muscarinic antagonists usuful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed.