| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new inhibiting agent containing a napyradiomycin compound represented by a specific formula as an active ingredient, capable of inhibiting the cell-adhesive molecule production of human venous endothelial cells within a range not expressing cytotoxicity, and useful as a cancer metastasis-inhibiting agent. SOLUTION: This agent for inhibiting the venous cell-adhesive molecule-1 production contains a napyradiomycin compound of formula I (R<1> is Cl, H; R<2> is H; R<3> , R<4> are each methyl, OH, or R<3> , R<4> form a ethylidene group together; R<5> is Cl, Br), preferably napyradiomycin SC of formula II, as an active ingredient. The napyradiomycin compound is obtained e.g. by culturing Streptomyces cyaneus (FERM P-15233) in a liquid culture medium in culture conditions comprising 30-37 deg.C and a pH of 7-8 under an aerobic condition for 12hr to 10 days, extracting the microorganism culture product or the culture supernatant with an organic solvent and further separating the napyradiomycin compound by a chromatography. |
